Modern high sensitive reagents for clinical chemistry

Currently laboratory medicine has entered a new phase: conversion from diagnosis statement, "when the disease is already", to the risk assessment of possible fatal abnormalities when they are still at asymptomatic sub clinical stage. Using modern methods of laboratory diagnostics during long-term monitoring of a large group of initially healthy individuals scientists found a correlation between the defined parameters and the appearance of a specific pathology in a certain time period. Thanks to this research a new class of reagents – predictors was introduced in the practice of clinical diagnostics laboratory.

Predictor is a compound which concentration increase is tightly connected with increasing risk of appearing of certain pathology. It was established that a concentration level of a predictor corresponds to quantitative indicator of relative risk of pathology appearance and its weight level.

Science development makes us to descend from classic reagents and use modern leading reagents.

FENOX Medical Solutions company has started a production of high sensitive specific proteins which have high diagnostic and prognostic relevance with immunoturbidimetry method.

Turbidimetry is a method used for measuring protein concentration based on changing of intensity of light dispersion in turbid solutions when a light stream passes through it. it is one of the most progressive method of modern laboratory diagnostics for determination of a quantity of specific proteins in blood serum, medullispinal liquid and urine. Method allows to evaluate a risk of appearance of serious pathologies at asymptomatic, sub clinical stage, to predict a state of a patient and to monitor efficiency of treatment.

For example determination of apolipoprotein A1 (Apo A1) together with apolipoprotein B (Apo B) and lipoprotein is a most accurate indicator of atherosclerosis development and a predictor of myocardium infarction.

Low concentrations of Apo A1 in both men and women is an indicator of a high risk of CHD. High concentration of Apo B is a strict indicator of high CHD risk. Measuring Apo B is also very informative in case of monitoring lipids reducing therapy. Method can be recommended as an alternative to measuring low density cholesterol of lipoproteins.

Scientists found a strict direct correlation between Apo B/Apo A1 ratio and high risks of fatal and sharp myocardium  infarction not depending from age, sex and race.  Apo B/Apo A1 ratio shows a risk of cardiovascular disease even when lipids level is normal.

Leading cardiologists from 10 countries offered in 2006 new international rules of assessment cardiovascular risks.

They state that:

  • Apo B is the most precise predictor of CHD;
  • Apo B is the most adequate indicator for monitoring efficiency of lipids reducing therapy;
  • Аpo В/Аpo А-1 indicator has higher precision in assessment of coronary risks of patients with asymptomatic CHD than all other indicating characteristics of cholesterol correlation.

Immunoturbidimetry determination of this parameters has lowe consumption than measuring lipids cholesterol.